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Discussion on Hydroxyzine dose amount?

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Patricia Snyder
New Member
Username: snyderpm

Post Number: 1
Registered: 2-2008
Posted on Friday, Mar 14, 2008 - 12:10 pm:   Edit PostPrint Post

For hives, I have been giving my horse Prednisolone along with Hydroxyzine at about 2mg/Kg. From my observation the Hydroxyzine has helped in that I was immediately able to reduce the amount of Prednisolone, and I am now down to 60mgs once a day. Previously when I tried to lower the dose to 120mg the hives would greatly increase. My question is do you think 2mg/kg could be a problem? I see that for Hydroxyzine you recommend 1mg/Kg. His actual dose is 450mg twice per day and he weighs about 900lbs.
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 20257
Registered: 1-1997
Posted on Friday, Mar 14, 2008 - 4:12 pm:   Edit PostPrint Post

Hmmm, I don't have any facts to back this up Patricia but in general but the chief side effect is sedation and if you are not having trouble with that you may be OK. Let me comment that 120 mg pred every other day is far better for long term use than 60 mg a day. Have you tried alternate day therapy? For an explanation of why this is see Treatments and Medications for Horses » Anti-inflammatories (NSAID's, Steroids, Arthritis Rx) » Prednisolone, Alternate Day Therapy.
DrO
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Patricia Snyder
New Member
Username: snyderpm

Post Number: 2
Registered: 2-2008
Posted on Friday, Mar 14, 2008 - 9:44 pm:   Edit PostPrint Post

I tried ADT at a higher dose and it didn't work for my horse and my vet poo pooed it. I just reduce one pill or 20mg at a time. At the end of the treatment we do every other day. It is hard to know what is the best, because every vet seems to have a different opinion. A vet friend of mine in another state wants me to put him on Transfer Factor, and the vet I use is totally against it. I read up on it, but don't have enough knowledge to know. A friend of mine with allergies took Transfer Factor for 2 years and got nothing.
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 20265
Registered: 1-1997
Posted on Saturday, Mar 15, 2008 - 9:26 pm:   Edit PostPrint Post

He pooed the idea of ADT??? For decades ADT has been the mainstay of long term steroid therapy in humans and all other species to avoid the important complication of adrenal suppression. Anyone who poos the idea of ADT when faced with the necessity of long term steroid use, hmmm...how do I put this nicely...has not considered the problem. It may well be that 500 mg every other day is less toxic than 120mg daily. What ADT regimens have you tried?
DrO
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Patricia Snyder
New Member
Username: snyderpm

Post Number: 3
Registered: 2-2008
Posted on Tuesday, Mar 18, 2008 - 11:08 pm:   Edit PostPrint Post

Considering the way you stated how the ADT should be used, I did not start at the appropriate dose. I did not read about it until I was down to a low does of Prednisolone, 4/20mg pills. When I skipped a day the hives came back enough to make me not want to do it again right away. Now I am down to giving him 2/20mg pills per day and he is doing good. Tomorrow I am going to try 1/20mg pill and see what happens. Also his allergy injections are at a level now that they should be helping him some if they are every going to do any good. More than ADT, I would like to know what you think about Transfer Factor for horses with a compromised immune system? Do you know personally of anyone who has put their horses on Transfer Factor when their horse has recurring hives, and they think it helped?
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 20289
Registered: 1-1997
Posted on Wednesday, Mar 19, 2008 - 6:34 am:   Edit PostPrint Post

The problem with hives is not a compromised immune system Patricia, in fact just the opposite: the immune system is over reacting.

The use of "transfer factor" at this time in horses for any condition is not supported by any science I can find. Considering the products I can find on the market, I find the notion of the oral ingestion of small proteins, which are likely to be digested away in the bowel before they are absorbed, is unlikely to be useful treatment. In human medicine where transfer factor is used experimentally against infections, it is injected.
DrO
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Janice Smith
New Member
Username: jrls

Post Number: 1
Registered: 2-2008
Posted on Friday, Apr 25, 2008 - 10:49 pm:   Edit PostPrint Post

Is there any difference between hydroxyzine hydrochloride and hydroxyzine pamoate in horses? According to the package insert, they are equivalent in humans. The HCl comes in a tablet and the pamoate in a capsule. I can get the pamoate in a larger quantity at a somewhat lower price per 50 mg capsule. Thank you for your help.
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 20549
Registered: 1-1997
Posted on Monday, Apr 28, 2008 - 8:02 am:   Edit PostPrint Post

Welcome Janice,
We have had this question several times before so run a search on hydroxyzine pamoate.
DrO
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Janice Smith
New Member
Username: jrls

Post Number: 2
Registered: 2-2008
Posted on Monday, Apr 28, 2008 - 11:24 am:   Edit PostPrint Post

Oops. I had done the search first, but somehow I missed it the first time. Thank you!
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kristen harding
New Member
Username: 6harding

Post Number: 1
Registered: 4-2008
Posted on Tuesday, Apr 29, 2008 - 2:55 pm:   Edit PostPrint Post

I'm also having trouble with hives in an 8 year old paint. He had the hives last year at the same time and we were able to keep them under control with 4 cc's of dex. every 4 days for about 6 weeks. My vet wants to do this again. My question is how long is too long? I have read the articles and still don't know the answer.

Thanks, Kristen
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 20564
Registered: 1-1997
Posted on Tuesday, Apr 29, 2008 - 6:28 pm:   Edit PostPrint Post

Welcome Kristen,
This is an excellent question but needs to be started in it's own discussion. Since you post in this area I am unsure you have seen the articles specifically on steroid use in horses. Check out Treatments and Medications for Horses » Anti-inflammatories (NSAID's, Steroids, Arthritis Rx) » Steroids, Overview of Antiinflammatory Use which deals with these issues. There is also a specfic article in that area on Dexamethasone. If after reviewing the articles you still have the question post it in that discussion forum by starting a new discussion. You will find the start a new discussion button at the bottom of the list of existing discussions.
DrO
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