Better information makes for healthier horses,
Horseadvice.com is where equine science and horse sense intersect.
|HorseAdvice.com » Diseases of Horses » Lameness » Treatment Methods »|
IRAP therapy for Arthritis in Horses
The first step to understanding what IRAP therapy is and it's role in the treatment of degenerative joint disease type of arthritis is to understand the acronym "IRAP". Let's explain the letters one at a time. The "I" stands for Interleukin-1 (abbreviated IL-1) which is a cytokine, one of the first ever described. Cytokines are produced by cells and and then diffuse to another cell and alters the behavior of that cell. This means cytokines are a type of locally acting hormone. Interleukin-1 (IL-1) is believed to be a major mediator of joint disease by communicating with cells in the joint and inducing the release of inflammatory products. In order to exert it's effects IL-1 must communicate with cells by means of a receptor on the target cell it effects. This cell receptor to IL-1 is abbreviated as IL-1R and is the "R" in the acronym. If you can block the IL-1R you are antagonizing the receptor's activation, so "A"ntagonizing is the "A" in IRAP. A protein has been identified that antagonizes the IL-1R is referred to as a IL-1Ra Protein which become the P in IRAP. To put it all together without the abbreviations could look like this: Interleukin-1 Receptor Antagonizing Protein. Inflammation can be a good thing but in degenerative joint disease the inflammation is excessive leading to further degeneration of the joint. IRAP therapy involves decreasing the effects of IL-1 with a protein. This article discusses IL-1 and it's role in DJD, the therapeutic options currently in use, and results of studies using this therapy in horses.
~Word Count: 1829 words (The average magazine page contains about 600 words);You have just read the introduction to one of our nearly 800 articles on horse care, diseases, and training. It includes a description of the contents of the unabridged version. As a guest you can purchase this article but better is to become a member and Join us at Horseadvice and take advantage of all the benefits we have to offer: Access to all the sites articles and discussions and posting questions and comments to the Discussion Boards.
~Last Updated: July 10, 2015;
There are 2 ways to access the complete article:
1: Article Purchase: $7 US for instant access to the unabridged article.
2. Join Horseadvice: Full Access for less than a cup of coffee a week.Recommended to those who wish to have full access to one of the finest equine resources anywhere and engage an equine veterinarian and experienced horsefolks with questions and discussions on all aspects of horses and horsemanship. 48$ US to join for an annual membership. You may cancel anytime online.
Uncertain if you want to become part of one of the finest most up-to-date equine resources in the world? Click Here for More Information!
|Home Page | Todays Discussions | Search | Top of Page||Administration|
is The Horseman's Advisor
Helping Thousands of Equestrians, Farriers, and Veterinarians Every Day
All rights reserved, © 1997 - 2016