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Discussion on Potential Role of Clostridium difficile in Anterior Enteritis
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Moderator:
DrO
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Posted on Tuesday, Dec 20, 2005 - 1:36 pm:
The cause of AE remains somewhat uncertain but at the 2005 AAEP in a presentation entitled Potential Role of Clostridium difficile Duodenitis Proximal Jejunitis toxigenic strains of Clostridium difficile were cultured from the nasogastric reflux of seven of seven (100%) horses with clinical AE but from none of the control samples. Additionally, no other known pathogenic clostridia were isolated from either group. Four of seven (57%) of the isolates possessed genes encoding for the production of both of the main toxins, toxins A and B, whereas three were variant strains that produced toxin B but not toxin A. Additionally, genes encoding for CDT were present in one isolate that also possessed the genes encoding for toxins A and B. Results of this study suggest that C. difficile may be a cause of AE. This gives the possibility of directly treating this sometimes fatal condition.
DrO
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