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Gentamicin and Aminoglycoside Use in Horses
Gentamicin and Aminoglycoside Use in Horses
Introduction
Gentamicin is a member of the family of antibiotics called amimoglycosides. Aminoglycoside antibiotics are useful for the treatment of gram negative bacterial and staph infections. Due to efficacy and cost they are frequently the first antibiotic choice where gram negative infections are suspected. However, their potential toxicity means care and judgement must be used with their administration. This article is about the uses, contraindications, toxic effects, dosages, and association drug rules that apply to this medication.
Chemistry
Gentamicin occurs as an off-white powder. The commercial injection is a straw-colored solution. Gentamicin sulfate for injection should be stored at room temperature (15-30?C); freezing or temperatures above 40?C should be avoided. In vitro inactivation of aminoglycoside antibiotics by penicillin family of drugs and the other beta-lactam antibiotics is well documented.
Uses
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