Erythromycin and Rifampin

Erythromycin and Rifampin Use in Horses

by Robert N. Oglesby DVM

Introduction

Introduction » Chemistry » Uses » Pharmacokinetics » Precautions and Adverse Effects » Overdosage » Drug Interactions » Doses » More Info & Discussions

Erythromycin is approved for use to treat infections caused by susceptible organisms and considered to be the treatment of choice when combined with rifampin for the treatment of Rhodococcus equi infections in foals. It is also useful when an animal is hypersensitive to penicillins. This article contains indications, dosages, and adverse effects of erythromycin and Rifampin.

Chemistry

Introduction » Chemistry » Uses » Pharmacokinetics » Precautions and Adverse Effects » Overdosage » Drug Interactions » Doses » More Info & Discussions

Erythromycin is a macrolide antibiotic produced from Streptomyces erythreus. It is a weak base that is available in several forms. It is a bitter-tasting, odorless or practically odorless, off-white to slight yellow, crystalline powder. Approximately 1 mg is soluble in 1 ml of water; it is soluble in alcohol. The more practical form for oral use in horses is erythromycin estolate occurs as a practically tasteless and odorless, white, crystalline powder. It is practically insoluble in water and approximately 50 mg are soluble in 1 ml of alcohol. Erythromycin estolate is also known as erythromycin propionate lauryl sulfate. Rifampin occurs as a red-brown, crystalline powder with a pKa of 7.9. It is very slightly soluble in water and slightly soluble in alcohol.

Uses

Introduction » Chemistry » Uses » Pharmacokinetics » Precautions and Adverse Effects » Overdosage » Drug Interactions » Doses » More Info & Discussions

                       
You have just read the beginning of this article. To access the unabridged article become a Member of Horseadvice.com! Your membership gets you instant access to this and over 600 articles on our site. Other benefits of your membership include participation in our discussion boards and access to our one button PubMed search tool for each topic.

Horseadvice can teach you to be a more knowledgeable horse owner which leads to a healthier horse and save you money. Really, we guarantee it. Come Join Us!
Viewing 2 topics - 1 through 2 (of 2 total)
Viewing 2 topics - 1 through 2 (of 2 total)
  • You must be logged in to create new topics.