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Discussion on Naquasone

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Heidi Hocker (Heidih)
Posted on Tuesday, Sep 3, 2002 - 3:31 pm:   Edit PostPrint Post

Hello Dr. O,

I have been looking for information on the drug Naquasone. It was recently prescribed by a vet for a horse in our barn that is having problems with stocking up. I was talking to the vet about my pregnant mare (almost 6 mos along) who has a history of ventral edema near the end of her pregnancies. He stated that he would most likely prescribe Naquasone for that, along with exercise and pressure hosing. (except it will be Feb, in an unheated barn).

I can't find any information here on Naquasone, except for 2 references in posts that just list it as a prescribed medication.

Can you tell me anything about it? Just for information, Naquasone looks like an extremely large yellow pill, approx. 21/2 inches long and an inch wide. You grind it up, mix it with water and give it by syringe into the mouth. I can't find any technical names for it.

Thanks for any help.

Heidi
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SallyH (Sallytwh)
Posted on Tuesday, Sep 3, 2002 - 5:41 pm:   Edit PostPrint Post

I looked Naquasone and find it has two main ingredients...Dexamethazone and Triclormethiazide.
Dexamthazone:
Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable in air. It is practically insoluble in water. The molecular weight is 392.47. It is designated chemically as 9-fluoro-11 b,17,21-trihydroxy- 16a-methylpregna-1,4-diene-3,20-dione. The empirical formula is C22H29FO5.

Tablets and Elixir

Dexamethasone tablets are supplied in six potencies, 0.25 mg, 0.5 mg, 0.75 mg, 1.5 mg, 4 mg, and 6 mg. Inactive ingredients are calcium phosphate, lactose, magnesium stearate, and starch. Dexamethasone tablets 0.25 mg also contain FD&C yellow 6. Dexamethasone tablets 0.5 mg also contain FD&C Yellow 10 and FD&C Yellow 6. Dexamethasone tablets

0.75 mg also contain FD&C Blue 1. Dexamethasone tablets 1.5 mg also contain FD&C Red 40. Dexamethasone tablets 6 mg also contain FD&C Blue 1 and iron oxide.

Dexamethasone elixir contains 0.5 mg of dexamethasone in each 5 ml. Benzoic acid, 0.1%, is added as a preservative. It also contains alcohol 5%. Inactive ingredients are FD&C Red 40, flavors, glycerin, purified water, and sodium saccharin.

TRICLORMETHIAZIDE:
Properties This medicine contains as active ingredient triclormethiazide, a thiazide-like diuretic. Thiazide or thiazide-like diuretics are prescribed to treat high blood pressure (hypertension). They are also used to reduce fluid accumulation in the body...irectic

FDA Approved Animal Drug Products
Online Database System
Drug Product Abstract
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030-136
(Rx)
Please note that the US Code of Federal Regulations (21 CFR version April 1, 2002) is the official source of regulatory information concerning approved animal drug products.
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Tradename(s) Naquasone® Bolus
Sponsor Schering-Plough Animal Health Corp.
Ingredient(s) Dexamethasone; Trichlormethiazide
Species Cattle, any use class
Route(s) Per Os
Drug Form(s) Bolus
Withdrawal Time(s) Cattle: Milk taken from animals during treatment and for 72 hours after the latest treatment must not be used for food.
--------------------------------------------------
CFR Indications This approved product is not described in the Code of Federal Regulations

--------------------------------------------------
No tolerances
Hope this is what you are looking for...Sally
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Robert N. Oglesby DVM (Dro)
Posted on Wednesday, Sep 4, 2002 - 7:03 am:   Edit PostPrint Post

Please note with dexamethasone in it, it should not be used in pregnant mares unless the benefit is considered to outweigh the risk of possible abortion. For more on this see the articles on steroids and dex.
DrO
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Heidi Hocker (Heidih)
Posted on Wednesday, Sep 4, 2002 - 8:35 am:   Edit PostPrint Post

Thank you Sally and DrO. That is exactly the information I was looking for. I will definitely not use it on my mare, unless there's a serious problem. In the past, her edema has only been a source of irritation, not a serious health risk. I do wonder though, why a vet would recommend a corticosteroid for a pregnant mare? Even I know that steriods are bad for pregnancy.

Thanks again

Heidi
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Robert N. Oglesby DVM (Dro)
Posted on Wednesday, Sep 4, 2002 - 10:54 am:   Edit PostPrint Post

Heidi,
I should have brought this up above, we have information on this type swelling at Equine Reproduction: Breeding and Foaling: Pregnant Mare Care and Nutrition.
DrO
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Elsie M. Darrah (Elsiedar)
Posted on Wednesday, Sep 4, 2002 - 5:20 pm:   Edit PostPrint Post

I wanted to add to the warning about giving any drug with dexamethosone in it. My mare was suffering form an insect sensitivty and has little scabs and itched real bad. She was die to foal in 10 days. The vet said he could relieve the itching with a shot of dexamethosone. I asked if it could hurt the foal. He said no and gave the shot.

The next morning when I went out to check the mare, she had a pink bag of fluid hanging out. I called the vet and before he got their the bag broke and the tissue was sucked back into the mare. The vet arrived and examined her and said the placenta separated leaving the foal without oxygen. The foal had to be turned and pulled. The vet had the foal half out when the mare decided to lie down and with a little assistance the foal was delivered. The foal was very weak, didn't seem to be able to nurse and had to have assistance getting up.

The foal's temperature went up and his lungs were congested. His joints became septic and he was lethargic. I took him to the vet college and after two days they recommended euthanizing him.

I believe the shot of dexamethosone triggered the birth and caused the separation of the placenta.

I am a sadder but wiser person about allowing shots to be given to a pregnant mare.

Elsie
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Heidi Hocker (Heidih)
Posted on Thursday, Sep 5, 2002 - 9:07 am:   Edit PostPrint Post

Dr. O, thanks for all the great information you make available. I had read the information in the Prgnant mare section. However, I am working with a new vet for this pregnancy (I moved from AZ to WI), so I had been discussing the problems she had in the past with him and the Naquasone came up. Obviously I won't be using it, and I may look further for a vet with more foaling experience.

Elsie, Thanks for the warning. I will definitely not be using anything with steroids in it, unless for some reason a life threatening emergency comes up. The foal is due in Feb. in WI, so bug bites shouldn't be too much of a problem.

Thanks again

Heidi
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