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Discussion on Diphenhydramine(Benedryl)
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New Member:
Tkranch
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Posted on Tuesday, Oct 22, 2002 - 4:40 pm:
This weekend I had my pregnant mare react to Triple-E FT+EHV from Ft.Dodge. She got extreme, hard, large welts that covered her from face to under the tail. She started shallow breaths about 60/min. I gave her 6 Benedryl tabs (not enough I know-she weighs over 1800lbs-Shire Horse). I finally got a vet to meet me in town for some injectable Benedryl/Diphenhydramine 50mg. I initially gave her two shots of 3cc ea. and after 20min noticed the welts softening. I was ready to give another injection but after 30min her respiration was down to 40/min. It took several hours but the welting finally subsided except in her breasts. My concern now is her pregnancy. She is about 3 months along. How did the reaction and the Diphenhydramine affect the fetus? Also, come time for her Rhino shots (Months 5,7 & 9)should I be ready with more diphenhydramine? kat
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Moderator:
DrO
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Posted on Tuesday, Oct 22, 2002 - 5:36 pm:
Hello Kat,
What was the concentration of the diphenhydramine injections? Why do you give the Venezueleun EE? I believe it has a reputation for higher reaction rates than the other vaccines.
DrO
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Member:
Tkranch
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Posted on Wednesday, Oct 23, 2002 - 8:20 pm:
I hadn't realized the higher risk of reaction with the Venezuelan EE. The diphenhydramine was 50mg/ml I believe (the vet loaded 2 syringes so I didn't see the bottle).
I'm not as concerned about the diphenhydramine affect to the fetus as I am about the reaction to the vaccine. We used Benedryl safely in the OB clinic I worked at.
Fort Dodge called me this morning to get more info to report the reaction and suggested that I don't use their products on this mare again----no problem.They also suggested that I predose her with Benedryl before any vaccination.(I estimate it will take about a dozen 25mg tablets--?)--I had given her 6 25mg Benedryl before we got the injectable.
I will try,again, to get Prodigy with havlogen (which I originally ordered but it wasn't available so they sold me Pneumabort)and get rid of the Pneumabort since they won't take it back.
This is a high risk mare since she has had 3 pregnancies that only 1 survived. We have had her for 1yr and don't know much on her history. I guess the only thing to do is wait till she is 5mo and do a palpation or possibly ANOTHER U.S.(she has had 3 at $88.00 ea).
I was wondering if you had come across a similar case and how the pregnancy outcome was.
Thankyou
Kat
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Moderator:
DrO
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Posted on Thursday, Oct 24, 2002 - 6:44 am:
The main concern to the feturs is the decrease supply of oxygen as the blood pressure goes down but there is no way to evaluate the risk of the reaction because of the variation in severity from horse to horse. You are correct, right now it is just a wait and see time. If I had to guess things are going to be OK. I have been lucky and in 20 years have never had an anaphalactoid reaction. We use the Fort Dodge products and would guess we gave over 10,000 indivdual injections over the past 5 years.
Concerning the diphenhydramine, considering its frequent use, fairly little is known about its effects on the fetus and pregnancy. In one study on rats, at higher doses, longer exposure, and earlier in pregnancy:
Neither maternal behavior nor milk production was affected by DPH treatment. Treated offspring showed an accelerated pinna unfolding, eye opening, and a delay of testes descent and vaginal opening. Both righting reflex and negative geotaxis development were accelerated, but prenatal exposure to DPH did not modify offspring locomotor activity. When tested as adults, a lack of sexual dimorphism in the open field activity of males and females was observed. No differences were observed between gonadal hormone levels of control and experimental groups of either sex. The findings suggest that prenatal DPH exposure influences physical and reflex development of rat pups.
Prenancy loss was apparently not a problem.
DrO
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Member:
Tkranch
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Posted on Friday, Oct 25, 2002 - 4:20 pm:
Thankyou for the information. I was a little concerned that DPH wasn't in your med list.
As much as I want to be told that the fetus is OK, I guess I will just have to wait. The mare's gums were pretty blanched and the amount of time from vaccine injection to full reaction was less than 2 hrs and probably another hr & half before injectable DPH. She seems to have recovered fully---I hope the fetus has also. Thankyou, Kat
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Member:
corinne
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Posted on Friday, Jan 26, 2007 - 7:16 pm:
Prayers for your baby and her baby. I have only seen these reactions in people as nurse and they can be scary especially with airway involvement but we always had O2, IV access, Epi, Bendryl etc and MD's to intubate if needed so even in the worst case senario we were prepared...I would about freak out to see it in a horse. Thank goodness you kept a level head! I will follow this thread just in case I run into such a reaction with my horse in the future...minus the pregnacy part.
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Moderator:
DrO
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Posted on Saturday, Jan 27, 2007 - 6:30 am:
Corinne, check the dates on the posts this baby is now a 5 year old horse.
DrO
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Member:
corinne
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Posted on Saturday, Jan 27, 2007 - 11:28 am:
I didn't mean to write baby it was a typo. Sorry I meant to write mare and her baby. I type too fast for my own good sometimes. 
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Moderator:
DrO
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Posted on Saturday, Jan 27, 2007 - 7:13 pm:
No that wasn't my point Corinne, it sounded like you were responding to a new post when this appears to be a discontinued thread. Though if Kat is listening, her profile indicates she still is a member, I would love to know the outcome.
DrO
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Member:
corinne
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Posted on Saturday, Jan 27, 2007 - 7:26 pm:
LOL. Oh you are right. Ooopppsssss. I tell you getting up for work at 2:30 in the morning kills me for the rest of the day. I think I went to the meds section because someone mentioned it was different in the site upgrade posts...obviously was tired, had a bit of a moment, and then replied to one! LOL. Thanks for keeping me on my toes. Going to take a nap!
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