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Discussion on Fluphenazine (Prolixin)

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Paintmom
Posted on Monday, Mar 15, 1999 - 6:41 am:   Edit PostPrint Post

Could anyone tell me something about the long acting tranquilizer named flufenzine? How long after you use the drug will it show up in a blood test? Would it show up in a DNA hair test? We bought a very calm horse in The middle of December and by the end of feburary we had a extremely hyper horse on our hands. Thanks!
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Marlane
Posted on Monday, Mar 15, 1999 - 6:42 am:   Edit PostPrint Post

I guess the main thing is dealing with her behaviour at the present time.She may have been drugged,if so then unless you wish to prove that she was and return her,then it is a matter of dealing with her behaviour.From my own experience some horses are naturally edgey for quite a while when they go to a new home.But then on the other hand there are a lot of factors that could also be affecting her,let us know.
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painted pony
Posted on Monday, Mar 15, 1999 - 6:44 am:   Edit PostPrint Post

Fluphenazine - one brand name is Prolixen - is a phenothiazine. This drug is an antipsychotic in humans. There is a long-acting form, fluphenazine decanoate which is given intramuscularly or subcutaneously in humans with an onset of action generally between 24 and 72 hours after administration. The effects of a single dose of the extended-action injectable drug in humans may last as long as 6 weeks in some patients. Indications (in humans): the management of psychotic conditions, effective in schizophrenia, and for production of a quieting effect in hyperactive or excited psychotic patients. (From the USP DI) Don't know anything about its use in horses.
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The Advisor Vet, RN Oglesby DVM
Posted on Monday, Mar 15, 1999 - 6:45 am:   Edit PostPrint Post

I have never used this drug in horses. Nor have I any information in any or the texts that I have. I can find a 10 year old reference of this drug causing agitation and repetitive motions in a horse. The horse was further sedated with another drug. It also caused Parkinson like symptoms in another horse. One article suggested it use was not uncommon in horses, but I have not seen any evidence of this myself. The Advisor Vet, RN Oglesby DVM
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rp
Posted on Monday, Jun 21, 1999 - 7:24 pm:   Edit PostPrint Post

Fluphenazine seems to have become increasingly poplular for hyper horses. It does not take the place of training, but tends to have the affect of having already "warmed-up" the horse without the work.
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pnewport
Posted on Wednesday, Jun 23, 1999 - 4:24 pm:   Edit PostPrint Post

I have used Prolixen on two different horses--one, my mare several years ago when she seemed "psychotic" during her hard heats. The vet who gave it to me was on the race track for years, a cattle rancher, etc., and he said he's used it hundreds of time with no ill effects. He said sometimes it turns a rank horse into a good horse and when the drug wears off they sometimes stay nice. The mare only needed it one time, one year. The gelding I'm using it on now is another case of calm when I bought him and excitable after gaining weight and getting fit. He has a good mind and it hasn't affected his stamina or desire to go. It just seems to have taken the edge off. I'm hoping he'll get used to group riding and stay that way. I didn't know this was a popular drug--first I'd heard of it.

Pam N.
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Laura Swain
Posted on Wednesday, Feb 9, 2000 - 3:50 pm:   Edit PostPrint Post

I just had Fluphenazine recommended to help keep my laid up horse chilled out, but I haven't done it yet. After reading the above info, I'm not sure I'm going to.
Laura
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Rodney D
New Member
Username: parker66

Post Number: 3
Registered: 3-2008
Posted on Thursday, Mar 27, 2008 - 4:06 pm:   Edit PostPrint Post

I strongly recommend Fluphenazine right after a horse is gelded. You have the results of the horse being cut right away without having to wait for the testosterone to be completely out of their system.
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 20349
Registered: 1-1997
Posted on Friday, Mar 28, 2008 - 6:42 am:   Edit PostPrint Post

I disagree Rodney, in general the potential adverse reactions and unknowns with this unapproved medication are too great for such a cavalier use. Besides, usually the castration itself will slow them down a little for a week or two.
DrO
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