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Cyproheptadine
Cyproheptadine Use in the Horse
Introduction
Cyproheptidine is a antihistamine that also has serotonin antagonist properties in the CNS. In horses and equines it has been useful for several unrelated horse issues including photic head shaking and Cushinoid disease of horses. This article describes its pharmacology, safety, and dosage in the horse and provides links to disease where it is use has been advocated in horses.
Pharmacology
Cyproheptadine is poorly studied in horses. Cyproheptadine acts like most antihistamines by competing for H1-receptor sites on cells. Antihistamines do not block histamine release. Cyproheptadine has significant antiserotonin activity and may have calcium channel blocking action as well. In other species it is well absorbed after oral administration but it's distribution is not well described. Probably metabolized in the liver with the metabolites excreted in the urine. Elimination is reduced in renal failure.
Safety
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