Discussion on Research Summary: Is Voriconazole the Ideal Systemic Anti-fungal in Horses?
Use the navigation bar above to access articles and more discussions on this topic.
| Author |
Message |
    
Robert N. Oglesby DVM
Moderator
Username: dro
Post Number: 19336
Registered: 1-1997
| | Posted on Tuesday, Oct 9, 2007 - 8:07 am: |   |
Here is a bit of research that has found a antifungal that is well absorbed when taken orally and has the potential for low toxicity. I would like to see a larger study of higher doses to measure the potential for toxicity. However this is good enough for me to move forward with fungal infections that are sensitive but suspect a course of treatment would be very expensive at this time. Maybe prohibitively so?
DrO
Am J Vet Res. 2007 Oct;68(10):1115-21.
Pharmacokinetics of voriconazole following intravenous and oral administration and body fluid concentrations of voriconazole following repeated oral administration in horses.
Colitz CM, Latimer FG, Cheng H, Chan KK, Reed SM, Pennick GJ.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Objective-To determine the pharmacokinetics of voriconazole following IV and PO administration and assess the distribution of voriconazole into body fluids following repeated PO administration in horses. Animals-6 clinically normal adult horses. Procedures-All horses received voriconazole (10 mg/kg) IV and PO (2-week interval between treatments). Plasma voriconazole concentrations were determined prior to and at intervals following administration. Subsequently, voriconazole was administered PO (3 mg/kg) twice daily for 10 days to all horses; plasma, synovial fluid, CSF, urine, and preocular tear film concentrations of voriconazole were then assessed. Results-Mean +/- SD volume of distribution at steady state was 1,604.9 +/- 406.4 mL/kg. Systemic bioavailability of voriconazole following PO administration was 95 +/- 19%; the highest plasma concentration of 6.1 +/- 1.4 mug/mL was attained at 0.6 to 2.3 hours. Mean peak plasma concentration was 2.57 mug/mL, and mean trough plasma concentration was 1.32 mug/mL. Mean plasma, CSF, synovial fluid, urine, and preocular tear film concentrations of voriconazole after long-term PO administration were 5.163 +/- 1.594 mug/mL, 2.508 +/- 1.616 mug/mL, 3.073 +/- 2.093 mug/mL, 4.422 +/- 0.8095 mug/mL, and 3.376 +/- 1.297 mug/mL, respectively. Conclusions and Clinical Relevance-Results indicated that voriconazole distributed quickly and widely in the body; following a single IV dose, initial plasma concentrations were high with a steady and early decrease in plasma concentration. Absorption of voriconazole after PO administration was excellent, compared with absorption after IV administration. Voriconazole appears to be another option for the treatment of fungal infections in horses. |
