Discussion on NSAID's and stomach irritation
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Message |
    
Diane Brezniak
Member
Username: Brezniak
Post Number: 19
Registered: 12-2003
| | Posted on Friday, Dec 17, 2004 - 12:58 am: |   |
Are there any NSAID's or other anti-inflammatories that do not irritate the stomach lining? Are there stomach protectants that can be used concurrently with Bute if a horse has an ulcer? |
Robert N. Oglesby DVM
Moderator
Username: Dro
Post Number: 11683
Registered: 1-1997
| | Posted on Friday, Dec 17, 2004 - 7:44 am: | |
Hello Diane,
First understand that NSAID's don't cause problems by directly irritating the lining: it is a pharmacological effect mediated through prostaglandins. For the treatment of ulcers including discussions on protectants see, Equine Diseases » Colic and GI Diseases » Gastric Ulcers.
DrO |
Diane Brezniak
Member
Username: Brezniak
Post Number: 20
Registered: 12-2003
| | Posted on Friday, Dec 17, 2004 - 12:11 pm: | |
Where can I find out more about the pharmacology of Bute then and how prostaglandins are involved? I have a mare that has been on a large dose of Bute for a while because of a serious founder episode. She has had blood tests for liver/kidney function and appeared to be tolerating it. However, I suspect that she is having some irritation of the stomach, maybe not ulcers yet but could be headed there. I have taken her off Bute but am looking for an alternative that would be easier on her stomach. |
Robert N. Oglesby DVM
Moderator
Username: Dro
Post Number: 11691
Registered: 1-1997
| | Posted on Saturday, Dec 18, 2004 - 10:36 am: | |
See Equine Medications and Nutriceuticals » Anti-inflammatories (NSAID's, Steroids, Arthritis Rx) » Phenylbutazone (Bute).
DrO
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