Discussion on Copper Peptides
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| Author |
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Tonya Bauer
Member
Username: pbauer
Post Number: 394
Registered: 10-2002
| | Posted on Monday, Feb 25, 2008 - 6:39 pm: |   |
Dear All,
Peruse at your leisure 
http://www.skinbiology.com/horsesanddogs.html
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Robert N. Oglesby DVM
Moderator
Username: dro
Post Number: 20134
Registered: 1-1997
| | Posted on Tuesday, Feb 26, 2008 - 6:39 am: | |
Initial research on copper peptides and wound healing have been positive however this research is preliminary and still much work needs to be done before any copper peptide product can be recommended for use on open wounds. Most important are independent toxicity studies (both local and systemic from the absorbed copper) and comparison with current "excellent therapy" practices.
DrO
Vet Dermatol. 2006 Dec;17(6):417-23.
Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits.
Cangul IT, GulNY, Topal A, Yilmaz R.
Department of Pathology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle/Bursa, Turkey.
In this study the clinical and histopathological effects of topically applied tripeptide-copper complex (TCC) and zinc oxide on open-wound healing in rabbits was evaluated. Eighteen New Zealand rabbits were divided into three groups: TCC, zinc oxide and no treatment. One full thickness wound was created on each side of the dorsal midline in each rabbit. Wound margins were traced on days 0, 7, 14, and 21 and topical TCC and zinc oxide were applied daily for 21 days to each rabbit in the respective treatment groups. The mean unhealed wound area was significantly smaller in the TCC than in the zinc oxide group on day 7, but it was significantly smaller in the TCC group than in to the control group on days 7, 14 and 21. The mean percentage of wound contraction on day 7 was significantly higher in the TCC than in the zinc oxide group; however, it was significantly higher in the TCC group than in the control group on days 7, 14 and 21. Median time for the coverage of the wound bed with granulation tissue was significantly shorter in the TCC group than in the other groups. Filling of the open wound with granulation tissue to skin level was significantly slower in the control group than in the other two groups. Neutrophil counts decreased regardless of the group in parallel with healing, while neovascularization was best observed in the TCC group. The results suggest that TCC is a better choice in the treatment protocols of open wounds in rabbits than zinc oxide. |
Tonya Bauer
Member
Username: pbauer
Post Number: 397
Registered: 10-2002
| | Posted on Tuesday, Feb 26, 2008 - 4:46 pm: | |
Dear DrO.,
I really appreciate your feedback...loved the excellent article!
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Tonya Bauer
Member
Username: pbauer
Post Number: 398
Registered: 10-2002
| | Posted on Tuesday, Feb 26, 2008 - 4:51 pm: | |
P.S. Except...that they had to do that to the rabbits!! |
