Discussion on Questions on use of Regumate
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| Author |
Message |
    
Sarah Woodman
Member
Username: Meggles
Post Number: 6
Registered: 12-2004
| | Posted on Thursday, May 19, 2005 - 5:50 pm: |   |
DrO. My mare has been on regumate now for almost a year to prevent her from having siezures and it has done so effectively. I have a few problems with the use of the regumate that I'm wondering if you can advise on...
1/ At this time of year I am having to increase the dose as intermittently her teats start to swell until quite large and leak a yellowy, waxy substance. Her behaviour also becomes quite hormonal i.e sensitive to touch etc. If I increase the dose for a few days this subsides and things get back to normal. Could you advise me what dose I should be feeding per kg of weight? At the moment she is on 10mls per day and weighs around 630kg. Sometimes this is clearly not enough for her, indicated by the side effects above, but I'm concerned about feeding too much.
2/ Is it possible to become tolerant to a certain dose? I seem to have had to increase the dose from the original 6mls to 10mls for the last few months, and now 15 mls due to the severely swollen teats and blatantly hormonal behaviour. I will aim to reduce this day by day, but my question is, will I keep having to increase the dose as time goes on?
3/ All references to regumate refer to 'long periods' as being perhaps a whole summer, for example. Meg is on it permanently. Are any side effects known yet? I would hate to be doing more harm than good.
4/ Could weight gain or a change in diet impact on the effectiveness of the drug?
Thank you.
Sarah |
Bob Stack R.Ph.
Member
Username: Bobs
Post Number: 12
Registered: 4-2005
| | Posted on Thursday, May 19, 2005 - 8:05 pm: | |
DEAR SARAH: WITH ALL THESE RESPONSES YOU NEED TO CHECK WITH THE VETERINAIAN BUT FROM A HUMAN STANDPOINT
1/ THE DOSE IS LOW, I THINK IT NEEDS TO BE INCREASED AND GIVEN CONSISTENTLY AND NOT CHANGED. THE SYMPTOMS YOU DESCRIBED IN HUMANS WOULD BE DUE TO ESTROGEN DOMINANCE. THE REGUMATE DOES FIGHT THE ESTROGEN DOMINACE.
2/ NO TOLERANCE SHOULD DEVELOP. THE DOSE MAY NEED TO BE ADJUSTED DUE TO HORMONAL CHANGES(MORE IN THE SPRING?)BUT, BASICALLY IT SHOULD STAY THE SAME FOREVER
3/THE SIDE EFFECTS, WEIGHT GAIN OR OVULATION CHANGES, SHOULD NOT BE SEEN WITH THIS DOSE. THE DOSE IS LOW SO I DO NOT FEEL THAT YOU WILL HARM YOUR HORSE. YOU HAVE TO WEIGH THE POSSIBLITY OF SIDE EFFECTS WITH THE SIDE EFFECTS OF SEIZURES. IF THE SIEZURES PUT THE HORSE IN DANGER PLEASE WEIGH THAT AGAINST A LOW DOSE OF A FAIRLY SAFE DRUG.
3/THE LONG PERIODS THAT THE REFERENCES ARE REFERING TO ARE PROBABLY FOR PREVENTION OF OVULATION AND NOT WHAT YOU ARE GIVING IT FOR.IT IS NOT APPLICABLE IN YOUR CASE.
4/ NO , WEIGHT GAIN OR DIET SHOULD NOT CHAHGE ANYTHING.
BOB STACK R.Ph. |
Helen Weedon
Member
Username: Cara2
Post Number: 120
Registered: 9-2002
| | Posted on Friday, May 20, 2005 - 5:52 am: | |
Hi Sarah,
Glad to hear that Meg is doing so well on regumate. Given your concerns, had you considered having her spayed? It is done as a standing operation so less risky and less expensive than a knock-down operation. It would probably save you alot of money over time too, especially if you can get your insurance to pay. Plus there is the fact that handling regumate is a risky thing for us girls. Would Leahurst be the nearest hospital to you? My vet suggested it when I twigged that Cara's seizures were linked with her seasons but as she is an appalling traveller I put it on the back-burner, plus of course I have no proof of my theory whereas you do.
Hugs to you both
Helen & Cara xx |
Sarah Woodman
Member
Username: Meggles
Post Number: 8
Registered: 12-2004
| | Posted on Friday, May 20, 2005 - 8:12 am: | |
Hi Helen
Good to hear from you! Pool House (Lichfield) would be my nearest veterinary hospital which is only 30 mins down the road but there seems to be a reluctance in the UK to carry out these operations. I guess now we know that the regumate works, our vet (who is excellent incidentally) may be prepared to consider this option. I'll discuss this with him and let you know the response. All the best.
Sarah. |
Robert N. Oglesby DVM
Moderator
Username: Dro
Post Number: 12899
Registered: 1-1997
| | Posted on Saturday, May 21, 2005 - 7:45 am: | |
Bob's responses seem right on Sarah.
DrO |
