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Robert N. Oglesby DVM
Moderator
Username: Dro
Post Number: 13385
Registered: 1-1997
| | Posted on Thursday, Jul 21, 2005 - 12:56 pm: |   |
Here is another study that provides support for the use of oral joint supplements containing glucosamine hydrochloride and chondroitin sulphate and has added to our knowledge of appropriate dosing. This work suggests that the commonly prescribed dosages may be low for maximal effect and a long way from toxic doses. We have changed our dosing recommendations in the article and it should be understood there are still many assumptions in these recommendations so there may be further updates in the not to distant future, see the article for more.
Equine Vet J. 2005 May;37(3):227-31.
Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism.
Dechant JE, Baxter GM, Frisbie DD, Trotter GW, McIlwraith CW.
Equine Orthopaedic Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.
REASONS FOR PERFORMING STUDY: Clinical trials in human and veterinary literature have documented the benefits of oral nutraceutical joint supplements containing glucosamine (GU) and chondroitin sulphate (CS) to treat mild to moderate osteoarthritis, but the effects of these components have not yet been conclusively determined. OBJECTIVES: To assess varying dosages of GU and CS on normal and interleukin-1alpha (IL-1) conditioned equine cartilage explants and rationalise the use of these products. HYPOTHESIS: Treatment would not be detrimental to cartilage metabolism and higher dosages and the combination of GU and CS would be more beneficial than lower dosages and. GU or CS alone. METHODS: Articular cartilage explants collected from the femoral trochlea and condyles were cultured in normal and IL-1 conditioned media. Treatment groups included 0, 12.5, 25,125 and 250 microg/ml concentrations of GU alone, CS alone, or GU+CS in combination. Glycosaminoglycan (GAG) synthesis and total GAG content in the explants and media were analysed. RESULTS: There were no detrimental effects of GU, CS or GU+CS on cartilage metabolism. High dosages of GU+CS reduced total GAG release into the media (degradation). CONCLUSIONS: Our results suggests that GU+CS may prevent cartilage GAG degradation. POTENTIAL RELEVANCE: The combination of GU and CS may be more effective in preventing or treating osteoarthritis in horses than either product alone. |
Aileen
Member
Username: Sunny66
Post Number: 885
Registered: 9-2002
| | Posted on Thursday, Jul 21, 2005 - 9:09 pm: | |
Thanks Dr. O! |
