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Discussion on Isoxsuprine?

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Bunny Delgado
Posted on Tuesday, Dec 7, 1999 - 6:50 pm:   Edit PostPrint Post

Has anyone heard of or used this supplement. It was mentioned to me by a trainer who wasn't sure of the spelling, but said they had used it as an anti-inflamatory on an arthritic horse with good results.

Bunny D
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Chris Mills
Posted on Wednesday, Dec 8, 1999 - 10:57 am:   Edit PostPrint Post

Bunny,

I've heard of giving Isox to horses with navicular syndrome.

I'm not sure it has an overwelming history of success for that.

It is probably in Dr. O's pharmacology section.

Cheers.
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Dr. Carol Artlett
Posted on Wednesday, Dec 8, 1999 - 1:40 pm:   Edit PostPrint Post

Hey Bunny,
My horse was on it for about 3 months because he had very poor hoof quality. It is believed that the drug increases the blood supply to the hoof and makes it grow quicker. His hooves did improve but I feel that it had more to do with the improvement in the quality of feed he was receiving compared to what he was getting prior to me purchasing him. Getting improvement in hoof quality takes time, there are no quick fixes and sometimes it just comes down to the luck of the genes. Isoxsuprine is really used for navicular and DrO told me when I posted about this previously that there was no evidence for increased blood supply/hoof growth in a normal horse. I do not know if it can be used in an arthritic horse.
Don't waste your money unless you absolutely have to. It is not a cheap drug.
Carol
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Jennifer Hodge (Griffyn)
Posted on Sunday, Oct 15, 2000 - 10:53 pm:   Edit PostPrint Post

Bunny,
My vet recently suggested this drug to me as a treatment option for my 14 year old gelding with navicular changes. I am also interested in hearing if anyone has had any positive experiences with the product, as it is fairly expensive and so far the research I've read hasn't sounded overwhelmingly positive.
Jenn
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Robert N. Oglesby DVM (Dro)
Posted on Monday, Oct 16, 2000 - 9:15 am:   Edit PostPrint Post

You will find our article on this drug with a lot of scientific reports at, Equine Medications and Nutriceuticals: Miscellaneous Drugs.
DrO
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Stacey Gieseking (Staceyan)
Posted on Wednesday, Dec 6, 2000 - 7:27 pm:   Edit PostPrint Post

Is this drug illegal when showing in rated shows of the AHSA and CHJA? I heard a vet say that it was legal but then some say that it isn't legal to use. So is it or isn't it? I tried to look it up in the AHSA rule book but I couldn't find it. Please help!!
Stacey
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Robert N. Oglesby DVM (Dro)
Posted on Thursday, Dec 7, 2000 - 8:41 am:   Edit PostPrint Post

You will find our article on this drug has the medication rules in it.
DrO
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Alicia Kost
Member
Username: Aannk

Post Number: 157
Registered: 6-2001
Posted on Friday, Mar 7, 2003 - 9:44 am:   Edit PostPrint Post

Dr. O.,
Your article says
"AHSA: forbidden under NFS and TS rules." What are NFS and TS rules? Does this mean it is forbidden at all AHSA shows? Just curious.
Alicia
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Cathy Miller
Member
Username: Buddil

Post Number: 29
Registered: 11-2001
Posted on Friday, Mar 7, 2003 - 10:01 am:   Edit PostPrint Post

Hi, my horse is on Isoxuprene for "navicular syndrome" and before I put him on this medication I did call AHSA to verify that it is a legal drug, due to hearing both it was and wasn't from fellow horsepeople. It is, indeed, a legal drug now due to so many horses with "navicular syndrome". I show in dressage. If you would like to inquire, you can send an email to them or call them, I believe their number is on the web site under USA Equestrian or AHSA will bring you to the link. Hope this will help you!
Cathy
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Alicia Kost
Member
Username: Aannk

Post Number: 158
Registered: 6-2001
Posted on Friday, Mar 7, 2003 - 10:29 am:   Edit PostPrint Post

Thanks, Cathy. Is there a link to the drug rules on the USAEq site? I haven't been able to find it. I remember hearing Lavender is forbidden, and I got a free bottle of a really nice smelling shampoo at an A show, which had, guess what, Lavender in it!!
Thanks,
Alicia
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Cathy Miller
Member
Username: Buddil

Post Number: 30
Registered: 11-2001
Posted on Friday, Mar 7, 2003 - 8:17 pm:   Edit PostPrint Post

Hi Alicia, I don't think there is a link, as I recall I phoned them and had a representative answer my question. They were very polite and helpful. I think they have an area on the website for emails and they can help you there, too. I once had a question regarding a bits legality and used their email for that and they answered it right away, very helpful! It is amazing what you would think is legal and the things that are not! I also needed to know if bute was legal and they gave me a recommended doseage that would be legal, 5 days low dose, then 2 days off and it would not build up to test at too high of a level. I always thought bute was forbidden, but not at the USDF lower levels, but it is FEI forbidden. Best of luck! Cathy
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Robert N. Oglesby DVM
Moderator
Username: Dro

Post Number: 7923
Registered: 1-1997
Posted on Saturday, Mar 8, 2003 - 4:26 pm:   Edit PostPrint Post

Isoxsuprine use to be considered a masking drug and was on both the No Foreign Substance Rule and Therapeutic Substance Rule. I went to the AHSA site to verify Alicia's comments and they are down with maintenance, so I will check again next week.
DrO
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Robert N. Oglesby DVM
Moderator
Username: Dro

Post Number: 7944
Registered: 1-1997
Posted on Tuesday, Mar 11, 2003 - 10:56 am:   Edit PostPrint Post

I can find no specific mention of isoxsuprine on either the USA Equestrian or the FEI site in there drug rules. So I called the USA Equestrian folks also and here is what I was told:
1) Permitted under the Therapeutic Substances rules for all disciplines.
2) Permitted under the Forbidden Substances rules for all disciplines with the exception of FEI and Endurance. For more and recommended withdrawl times, see Equine Medications and Nutriceuticals Miscellaneous Drugs Isoxsuprine.

If you assume this is a effective medication it is difficult to see how this medication could possibly comply with the spirit of the No Therapeutic Substance rules (Article 409). I wonder if it is possible that it might slip by because there is either no measuarble physical effect after oral administartion or because almost no isoxsuprine (less than 3%) is absorbed from the digestive tract so there is little to measure in the blood? I leave you with this latest review of isoxsuprene use in the horse:

J Vet Pharmacol Ther 2002 Apr;25(2):81-7
Isoxsuprine hydrochloride in the horse: a review.
Erkert RS, Macallister CG.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Isoxsuprine hydrochloride has been suggested for use in horses for treatment of navicular syndrome and laminitis. The drug has been shown to be a beta-adrenoreceptor antagonist with beta-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. In addition, the drug is capable of decreasing blood viscosity and platelet aggregation. Studies have shown i.v. isoxsuprine to have a plasma half-life of <3 h with a large apparent volume of distribution. Cardiovascular effects resolve rapidly following i.v. administration, but are absent with oral dosing. Oral bioavailability is 2.2% with a high first pass effect. Isoxsuprine has an apparent affinity for melanin that may contribute to extended renal excretion. Clinical trials appear to support the use of isoxsuprine for treatment of navicular disease. However, poor bioavailability, lack of cardiovascular effects following oral administration, superficial support in clinical trials, and new evidence regarding the pathogenesis of navicular syndrome indicate that the use of isoxsuprine for treatment of navicular syndrome or laminitis is questionable at best.

DrO
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Robert N. Oglesby DVM
Moderator
Username: Dro

Post Number: 7945
Registered: 1-1997
Posted on Tuesday, Mar 11, 2003 - 11:27 am:   Edit PostPrint Post

Cathy I almost forgot, corrections to The Advisors factual data always brings a reward. Thank you for helping correct the information on isoxsuprine rule changes. 3 months will be added to your membership free.
DrO
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Alicia Kost
Member
Username: Aannk

Post Number: 159
Registered: 6-2001
Posted on Wednesday, Mar 12, 2003 - 12:52 pm:   Edit PostPrint Post

Dr O.,
I agree with your assessment of the Article 409, which is why I thought it must be prohibited. Thanks for clearing it up.
Alicia
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Cathy Miller
Member
Username: Buddil

Post Number: 31
Registered: 11-2001
Posted on Thursday, Mar 13, 2003 - 5:19 pm:   Edit PostPrint Post

Thanks Dr. O., 3 months is great!

Cathy
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estrella99
Member
Username: estrella

Post Number: 22
Registered: 5-2007
Posted on Friday, Sep 25, 2009 - 5:21 pm:   Edit PostPrint Post

Hello! So my little mare foundered, maybe sorta. She doesn't react to the hoof testers, no heat, no pulse. Well she does have a pulse but not the founder pulse. Not in any type of distress..just started sore on one foot, then both..and seemed unhappy, stiff. so vet treated for founder. Banamine (sp?), I use it enough so I should know..and..drum roll...Isoxuprine! 12 tabs 2x's a day..(under vet's direction). Then stop the banamine..just isoxuprine..with the recommended treatment..she didn't drink alot, wasn't eating well...looked terrible, you know "green". So stopped the Isoxuprine..changed to 1 gram of bute..she started feeling better...had a vet check..one foot still pretty sore..recommended restart Isoxuprine 2 days then off bute or banamine..she again didn't drink and looked like she felt horrible. So acting as a freelance vet..took her back off the Isoxuprine, back on 1 gram of bute 1x a day..she's happy not 100% sound..but at least looking like we are moving in the right direction. I throw in Ulcerguard. So question...can Isoxuprine make them queezy? Should have checked here first before I ever gave it...oh yea, 2 weeks into the soreness..Shoe boil! Ran 102.2 (on 1 gram bute). Vet back out and then Uniprim plus all of the other stuff. We are complete on the antibiotic treatment.
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Robert N. Oglesby DVM
Moderator
Username: dro

Post Number: 23801
Registered: 1-1997
Posted on Saturday, Sep 26, 2009 - 11:37 am:   Edit PostPrint Post

Hello estrella,
We cover your question and more in the article on this subject. To get to it quickly go to the top of the page and click on » Isoxsuprine ».
DrO
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