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| Author |
Message |
    
DELIVORGIA HELEN
| | Posted on Thursday, May 25, 2000 - 12:30 pm: |   |
A horse was found positive in a dopping control test, with Guaifenesin. Anybody knows what that is? |
Dr. Carol Artlett
| | Posted on Thursday, May 25, 2000 - 1:23 pm: | |
It is the glyceryl ester of guaiacol C10H14O4. I assume this is from guaiac, a resin from the wood of trees of the genus Guajacum. |
Lois Berenyi
| | Posted on Thursday, May 25, 2000 - 3:52 pm: | |
If it's the same thing I take for allergies it is the generic name for a decongestant that works by thinning mucus. |
Dr. Carol Artlett
| | Posted on Friday, May 26, 2000 - 1:12 pm: | |
Yes, it can be used as an expectorant! |
Robert N. Oglesby DVM
| | Posted on Tuesday, May 30, 2000 - 10:08 am: | |
Guaifenesin may also be known as glyceryl guaiacolate, GG, or guaiphenesin. In very high doses quaifenesin is both a sedative and muscle relaxant used frequently in horses:
Pharmacology - While the exact mechanism of action for the muscle relaxant effects are not known, it is believed that guaifenesin acts centrally by depressing or blocking nerve impulse transmission at the internuncial neuron level of the subcortical areas of the brain, brainstem and spinal cord. It relaxes both the laryngeal and pharyngeal muscles, thus allowing easier intubation. Guaifenesin also has mild intrinsic analgesic and sedative qualities. Guaifenesin causes an excitement-free induction and recovery from anesthesia in horses. It pro- duces relaxation of skeletal muscles, but does not affect diaphragmatic function and has little, if any, effects on respiratory function at usual doses. Possible effects on the cardiovascular system include transient mild decreases in blood pressure and increases in cardiac rate. Gastrointestinal motility may be increased, but generally no adversity is seen with this. Guaifenesin potentiates the activity of preanesthetic and anesthetic agents.
Uses/Indications - In veterinary medicine, guaifenesin is used to induce muscle relaxation and restraint as an adjunct to anesthesia for short procedures (30-60 minutes) in large and small animal species. In human medicine, guaifenesin has long been touted as an oral expectorant, but definitive proof of its efficacy is lacking. I have seen it in cough formulations for horses but the stuff is so bitter it amazes me folks can get it down the horse.
DrO |
Borderline Farm Ltd (Border)
| | Posted on Tuesday, Sep 11, 2001 - 11:10 am: | |
Is this drug regulated by the AHSA? I have a stallion who is very well behaved, but the moment we walk in the show ring he gets this huge rush. What I would call an adrealin (spelling?) rush. Almost uncontrollable. He is a "roarer" and when he gets "up" in the ring his breathing is worse, then I am battling the rush from hormones, and his anxiety because he cant get enough air. I have used ACTH with no success. He is quiet and well behaved until he actually goes in the ring. I have also thought .. o.k its just a training issue, but its not, it is solely hormonal, or chemical. This sounds like exactly what he needs. Have even gone to schooling shows where they dont test. Put 1/4cc of ace IV and he walks in the ring like a puppy dog!! Any help would be appreciated. I have tried ACTH, Dex (up to 6cc's), B1, and can not due to AHSA rules us Valerian, or Tryptophane. This horse is eating a low carb, no corn, high fat diet. |
Robert N. Oglesby DVM (Dro)
| | Posted on Wednesday, Sep 12, 2001 - 5:43 am: | |
Yes, being a sedative it is forbidden under both sets or rules.
DrO |
