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Discussion on Gastoguard and cimedatine used together
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Member:
Fpony
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Posted on Sunday, Sep 12, 2004 - 8:55 am:
Hi Dr. O,
My pony,Foxy, Has been on Cimedatine (1000 mg) 3 times a day for severe melanoma. (three month now)He has had a bad summer with his uveitis and has been on banamine at 300 lb doses 2 times a day while we were fussing with meds for his eye. Then one morning after accidently eating my horses ration (same feed that Foxy gets but had a cup of oil in it and thro-l) he stopped eating and became very quite. Some lying down but no thashing or rolling. I had just stopped the banamine the night before as his eye was doing better but I then gave him a 600lb dose as i thought he was colicing.
To get to the chase , my vet thought he may have an ulcer from all the banamine this summer and as i had gasto guard on hand from my horse, she had me treat him with that. After the second day he started to eat some and by the third day was back to normal.
Ok, one of his very large melenoma had shrunk considerably and I hate having him off the cimedatine (5 days now) can I give him the gasto guard and his dose of cimedadine together. My vet wanted me to give gasto guard for a week and then she wants to increase the dose of cimedatine and stop the gasto guard. Will the ulcer really heal without the gasto guard and just cimedatine?
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Moderator:
DrO
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Posted on Sunday, Sep 12, 2004 - 11:34 am:
Excellent to hear about your success with the melanomas. With what we know now, high doses even 4 times daily with cimetidine will not heal equine gastric ulcers. On the other hand I am uncertain from the information above you have ulcers. Many horses have small or recurrent bouts of colic like you describe that don't have ulcers.
I cannot find any safety studies with the use of both these drugs nor can I find any reports of toxicity. There is concern about both of these drugs and because they may effect other drugs particularly those orally ingested (do to ph change in the stomach) or processed by the liver (do to altered cytochrome enzyme activity).
DrO
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