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Discussion on Research Summary: Cob Normand horses and PSSM.
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Moderator:
DrO
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Posted on Wednesday, Apr 30, 2008 - 7:25 am:
11% of Cob Normand horses show histological changes consistent with polysaccharide storage myopathy.
DrO
Vet Pathol. 2008 Mar;45(2):154-8.
Polysaccharide storage myopathy in cob normand draft horses.
Larcher T, Herszberg B, Molon-Noblot S, Guigand L, Chaffaux S, Guerin G, Cherel Y.
Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 +/- 21.4 microm) compared with normal ones (57.3 +/- 19.7 microm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.
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