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Discussion on Research Study: Dermal Elastin and Chronic Progressive Lymphoedema
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Moderator:
DrO
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Posted on Friday, Feb 13, 2009 - 10:51 am:
Supporting current theories of a genetic degenerative disease of the lymphatic vessels this report identifies a defect of the dermal elastin in the lymphatic walls.
DrO
J Comp Pathol. 2009 Jan 13.
Quantitative and Qualitative Evaluation of Dermal Elastin of Draught Horses with Chronic Progressive Lymphoedema.
De Cock HE, Van Brantegem L, Affolter VK, Oosterlinck M, Ferraro GL, Ducatelle R.
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus 3 Eiken, D.U 012, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Chronic progressive lymphoedema (CPL) in horses, a disease of certain draught breeds, is associated with altered elastin metabolism. The characteristic lesions are seen in the skin of the lower (distal) limbs. This study was based on horses of susceptible breeds, with and without CPL, and on horses of a non-susceptible breed. Skin samples were obtained for examination from the neck (considered a non-affected region) and from the distal limb. The skin lesions were characterized histologically and the dermal elastic fibres were evaluated morphologically and quantitatively. In all horses the mean elastin concentrations were highest in the superficial dermis, gradually decreasing in the mid-dermis and deep dermis. As compared with horses of a non-susceptible breed, affected horses had increased amounts of dermal elastin in both the distal limb and neck, while non-affected horses of a susceptible breed had decreased amounts. The findings support an earlier hypothesis that CPL of horses is a generalized disease. Reduced efficiency of the elastic network in supporting the dermal lymphatics may explain the development of CPL.
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