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Discussion on New Article: Malignant Hyperthermia in Horses
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Moderator:
DrO
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Posted on Friday, May 29, 2009 - 11:14 am:
Malignant hyperthermia is a autosomal dominate genetic disorder of that rears it's head during anesthetic episodes. Symptoms of the disease is the anesthetized or post recovery horse displays a run away fever that can go high enough to be life threatening. This hypermetabolic response is usually do to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine. In some horses it may exhibit with stresses such as vigorous exercise and heat and can potentiate the problems associated with genetic rhabdomyolysis (GYS1 mutation) like Polysaccharide Storage Myopathies (EPSM and PSSM). This article discusses the genetic defect, pathogenesis, symptoms, treatment, and prognosis of malignant hyperthermia in horses.to access article click here.
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