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Discussion on Research Summary: Pregnant Mare and Granulosa Cell Tumor
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Moderator:
DrO
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Posted on Saturday, Feb 25, 2012 - 7:14 pm:
Most mares with GCT's may have trouble settling due to hormonal imbalances but here was an exception or she may have developed the tumor after conception.
DrO
N Z Vet J. 2012 Mar;60(2):160-3.
Granulosa theca cell tumour in a pregnant mare: concentrations of inhibin and testosterone in serum before and after surgery.
Gee E, Dicken M, Archer R, Herdan C, Pauwels F, Drayton B.
Source
a Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11222 , Palmerston North 4442 , New Zealand.
Abstract
Abstract
CASE HISTORY:
A 14-year-old Thoroughbred mare was presented for evaluation of a rapidly enlarging ovary at 73 days gestation. The mare's owner reported behavioural changes in the mare since she returned from stud, notably aggression towards other horses.
CLINICAL FINDINGS:
Transrectal palpation and ultrasonography of the reproductive tract revealed a viable pregnancy, an enlarged, multiloculated right ovary, and a normal-sized left ovary with a corpus luteum present. Concentrations of inhibin and testosterone in serum were 13.8 ng/mL and 1,150 pg/mL, respectively, being markedly higher than reference ranges. Concentration of progesterone was 4.5 ng/mL, consistent with the presence of functional luteal tissue. A presumptive diagnosis of a granulosa theca cell tumour (GTCT) was made, and the ovary was surgically removed. Histopathological examination of the removed ovary confirmed a benign GTCT. At 31 days after surgery concentrations of inhibin in serum had decreased 18-fold, and testosterone had decreased 10-fold. Pregnancy was reconfirmed at 115 days gestation by rectal palpation and transrectal ultrasonography.
DIAGNOSIS:
Granulosa theca cell tumour associated with elevated concentrations of inhibin and testosterone in serum.
CLINICAL RELEVANCE:
While ovarian enlargement and aggressive behaviour may be considered normal in some pregnant mares, a GTCT should be included as a differential diagnosis. Measurement of concentrations of inhibin and testosterone in serum are useful to support a presumptive diagnosis of GTCT in mares.
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