|
|
Discussion on Research Summary: New Cause for Kidney Disease?
|
| Author |
Message |
Moderator:
DrO
|
Posted on Sunday, Feb 10, 2013 - 3:51 pm:
You often read scientific and veterinary reports and though the information is interesting you wonder what possible use can it be? With no standard diagnostic technique and lack of a effective antiviral...? But this caught my eye so doing a little studying I find this family of viruses are very common in many animals including nonmammals. Interestingly while the antiviral drugs have not been that useful the antibacterial fluoroquinolones have inhibited replication (Sharma BN, Li R, Bernhoff E, Gutteberg TJ, Rinaldo CH (2011) Fluoroquinolones inhibit human polyomavirus BK (BKV) replication in primary human kidney cells. Antiviral Res). So you have a horse with unexpected kidney disease, you biopsy the kidneys, and be sure you ask to have the cells evaluated for viral disease, then consider a fluoroquinolone (see antibiotic section for more on these). It is a bit of a long shot but may make a difference.
DrO
Vet Pathol. 2013 Feb 4.
Polyomavirus-Associated Nephritis in 2 Horses.
Jennings SH, Wise AG, Nickeleit V, Maes RK, Cianciolo RE, Piero FD, Law JM, Kim Y, McCalla AC, Breuhaus BA, Roberts MC, Linder KE.
North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.
Abstract
Polyomaviruses produce latent and asymptomatic infections in many species, but productive and lytic infections are rare. In immunocompromised humans, polyomaviruses can cause tubulointerstitial nephritis, demyelination, or meningoencephalitis in the central nervous system and interstitial pneumonia. This report describes 2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomavirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans.
|
|
|
