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  Discussion on Glucosamine product
Author Message
Member:
Nadia

Posted on Sunday, Apr 2, 2006 - 8:55 am:

Hi, Dr. O,

This is the information that is listed on a Glucosamine product:

Glucosamine Joint Liquid For Horses Profile High Potency Oral liquid Glucosamine HyDrOchloride for Horses.

What is Glucosamine?
Glucosamine is a naturally occurring compound for the body’s production of joint lubricants and components necessary to maintain healthy cartilage and joint function.

Why use Glucosamine HyDrOchloride?
Animal and cartilage culture studies show that glucosamine hyDrOchloride is equal to or better than other forms of glucosamine in helping cartilage cells. Glucosamine HyDrOchloride is 99% pure, while Glucosamine Sulfate is only 74% pure, because it must be stabilized by a salt. Sulfate is removed from the glucosamine during
digestion and transport. The sulfate is excreted and will not materially affect cartilage.

Why not add ChonDrOitin?
ChonDrOitin sulfate has an approximate molecular weight of 14,000 and Baici showed that it is basically too large to be absorbed from the small intestine into the blood stream as is.*

*Analysis of Glucosaminoglycans in Human Serum after Oral Administration of ChonDrOitin Sulfate,” A. Baici et at; Rhematol Int 12: 3, 81-8 (1992).


Do you agree with this statement about ChonDrOitin not being useful? Could this be an old analysis and as there are recent studies indicating that ChonDrOitin with Glucosamine is the most effective combination for a joint product?

Thank you.
Moderator:
DrO

Posted on Sunday, Apr 2, 2006 - 10:02 pm:

Right now the products with the combination are the ones that are showing efficacy. Would they be as effective without the chonDrOitin is unknown. Even if the above statement is true, it may be a breakdown product that has action, or not. The following paper addresses this possibility:
Proc West Pharmacol Soc. 2004;47:50-3.
On the bioavailability of oral chonDrOitin sulfate formulations: proposed criteria for bioequivalence studies.
Verges J, Castaneda-Hernandez G.

Bioiberica, Scientific Medical Department, Plaza Francesc Macia 7, 08029 Barcelona, Spain. jverges@bioiberica.com

ChonDrOitin sulfate (CS) is a symptomatic slow-acting drug for osteoarthritis (SYSADOA). It should be noted, however, that there is a CS formulation approved as a drug in Europe, with evidenced efficacy and safety demonstrated by clinical trials in osteoarthritic patients. This formulation should therefore be considered as the reference product. This CS is manufactured by Bioiberica (Spain), commercialized in Europe by IBSA (Switzerland) and Bioiberica, and in the United States by Nutramax. Hence, all other CS formulations must demonstrate their bioequivalence with the reference product. Pharmacokinetic studies have shown that oral exogenous CS is absorbed as several metabolites, and the active moiety has not yet been identified. It is thus difficult to establish bioequivalence from plasma concentration against time curves. However, the FDA permits bioequivalence studies comparing the time course of the pharmacological response with two formulations of the same compound. It has been reported that the time course of CS response can be fitted to a modified Hill equation, as follows: E-E0=[(Emax x Ty )/(T50y+Ty)]. Where E is the effect at time T, E0 is the basal effect, Emax is the maximal effect, T50 is the time required to achieve 50% of the maximal effect and y is the sigmoid slope factor. Hence, it is proposed that a generic CS can be compared to the reference product using the Emax, T50, and y values derived by non-linear regression fitting to the modified Hill equation. The reference/test formulation ratio with the 90% confidence intervals (CI) can thus be estimated. If CI for each parameter ratio lies within 0.8-1.2, both CS formulations can be considered as bioequivalent. In the absence of such bioequivalence studies, physicians and patients are advised to use the reference product to obtain the maximal benefit in terms of efficacy and safety.

DrO
Member:
Nadia

Posted on Saturday, Apr 8, 2006 - 7:36 am:

I am not really sure what the above article is saying. What is a breakdown product?

What is your opinion on the using the combination of Glucosamine/CS vs just Glucosamine?

Thanks.
Moderator:
DrO

Posted on Saturday, Apr 8, 2006 - 9:04 am:

To repeat my opinion from above, "right now the products with the combination are the ones that are showing efficacy". Breakdown products are the chemicals a larger chemical is broke down to by the process of digestion.
DrO
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